4-(trifluoromethoxy)benzyl chloride

4-(trifluoromethoxy)benzyl chloride - Names and Identifiers

Name	4-(trifluoromethoxy)benzyl chloride
Synonyms	4-trifluoromethoxybenzyl chloride 4-(TRIFLUOROMETHOXY)BENZYL CHLORIDE 4-(trifluoromethoxy)benzyl chloride α-Chloro-4-(trifluoromethoxy)toluene [5-(trifluoromethyl)furan-2-yl]methanol alpha-chloro-4-(trifluoromethoxy)toluene 1-(chloroMethyl)-3-(trifluoroMethoxy)benzene 1-(CHLOROMETHYL)-4-(TRIFLUOROMETHOXY)BENZENE 1-(Chloromethyl)-4-(trifluoromethoxy)benzene 1-(chloromethyl)-3-(trifluoromethoxy)benzene Anti-Trifluoride Mathoxyphenyl Benzyl Alcohol Chloride Benzyl
CAS	65796-00-1
InChI	InChI=1/C6H5F3O2/c7-6(8,9)5-2-1-4(3-10)11-5/h1-2,10H,3H2

4-(trifluoromethoxy)benzyl chloride - Physico-chemical Properties

Molecular Formula	C8H6ClF3O
Molar Mass	210.58
Density	1.34
Boling Point	72 °C
Flash Point	61°C
Vapor Presure	0.693mmHg at 25°C
Appearance	clear liquid
Color	Colorless to Almost colorless
Storage Condition	Refrigerator
Refractive Index	1.4520-1.4560
MDL	MFCD00052326

4-(trifluoromethoxy)benzyl chloride - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	1760
Hazard Note	Corrosive
Hazard Class	8
Packing Group	III

4-(trifluoromethoxy)benzyl chloride - Introduction

Trifluoromethoxybenzyl chloride, chemical formula C8H5ClF3O, is an organic compound with the following properties and uses:

Nature:
-Appearance: colorless liquid
-Melting point:-25°C
-Boiling Point: 87-88°C
-Density: 1.42g/cm³
-Solubility: Soluble in organic solvents such as ether and dimethylformamide

Use:
-Trifluoromethoxy benzyl chloride is an important organic synthesis intermediate, which is widely used in the synthesis of drugs and pesticides. It can be used to synthesize benzothiazole compounds, benzotriazole compounds, 4-piperidinol compounds, etc.
-Trifluoromethoxybenzyl chloride is also used as a chemical reagent and catalyst.

Preparation Method:
The preparation method of trifluoromethoxy benzyl chloride is generally prepared by reacting trifluoromethanol with benzyl chloride. The specific steps include reacting trifluoromethanol and benzyl chloride in the presence of barium chloride at low temperature for a period of time, and then distilling to obtain the product.

Safety Information:
-Trifluoromethoxybenzyl chloride is an organic chlorine compound, and attention should be paid to its irritation to the skin, eyes and respiratory system. Use appropriate protective equipment, including goggles, gloves and protective clothing.
-Avoid inhaling its vapors or touching its skin. In the case of accidental contact, rinse immediately with plenty of water and seek prompt medical attention.
-Store away from fire and oxidant, avoid high temperature and direct sunlight.

Last Update：2024-04-09 02:00:47